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The Keap1Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases
Nov 2020;510:160-169
Melanotan II is a synthetic cyclic lactam heptapeptide of approximately 1024 Da, derived from alpha-MSH, acting as a non-selective agonist at MC1R, MC3R, MC4R and MC5R
In the AMY 1 R and AMY 3 R Y37 rAmy interacts with residues in the respective RAMP and the CTR ECD, however the small side chain of P37 Cagri is completely buried by the surrounding CTR ECD residues, forming extensive hydrophobic contacts with W79 ECD and no direct interactions with either RAMP1 (AMY 1 R) or RAMP3 (AMY 3 R), again consistent with the restrictive interactions formed by Pro32 sCT with the CTR ECD
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