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Clinical trials show tirzepatide produces greater average weight loss (15-22% of baseline) compared to semaglutide (10-17% of baseline) in most populations
This is called slower gastric emptying
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Additionally, its not uncommon to experience less weight loss in the first month, as you need time to adjust to the treatment plan and implement healthier lifestyle choices
Third, given the relatively recent introduction of GLP-1 RAs as antidiabetic treatments, the median follow-up duration in this study may have been too brief to adequately assess the long-term risk of cancer development
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