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Central appetite suppression: Amylin crosses blood-brain barrier Activates area postrema (brainstem) Also acts on nucleus accumbens Direct satiety signaling Reduces desire to eat Different brain pathways than GLP-1 3

We have therefore scored specific activities of alpha class GSTs with cumene hydroperoxide (CuOOH) as an organic hydroperoxide representing the peroxidase activity of GSTs (Seeley et al., 2006), trans -2-nonenal representing reactive ,-unsaturated aldehydes formed by lipid peroxidation (Berhane et al., 1994), and phenethyl isothiocyanate (PEITC) representing dietary exposure to isothiocyanates in cruciferous vegetables (Zhang et al., 1995)

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