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For this population-based study, researchers used medical records from about 45 million people in the United States listed in the TriNetX real-time federated health research network who all had at least one outpatient or inpatient doctor visit between 2011 and 2023
HS mediates cardioprotective effects through dual mechanisms: conventional pathways (e.g., antioxidant response, mitochondrial bioenergetics enhancement) and novel processes, including epigenetic regulation and inhibition of pathological programmed cell death, thereby maintaining cardiovascular homeostasis
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