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GLP-1 medications work by mimicking a hormone that regulates blood sugar, slows digestion, and reduces appetite

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In diet-induced obesity (DIO) mouse models, 5-Amino-1MQ administered intraperitoneally produced a 7% reduction in body weight over 11 days compared to vehicle-treated controls, despite no change in food intake

The results revealed an average 14.9% reduction in body weight from baseline during 68 weeks of treatment with semaglutide 2.4 mg plus a lifestyle intervention, compared with just a 2.4% reduction in the placebo plus lifestyle intervention group