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While human clinical trials remain limited, the consistency of positive results across different injury types and animal species has generated significant interest in the biohacking and athletic communities
The family of small Rho-GTPases, Rho, Rac and Cdc42, are important regulators of microtubule growth and stabilization [40,41,42,43,44,45,46] and are activated downstream of integrin engagement [47,48,49]
Thus, excessive production of ROS mediates hyper-inflammation and generation of cytokine storm that directly determine both ARDS development and ARDS course severity
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