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Quick Answer: GLP-1 medications show clinically meaningful average weight loss in large-scale peer-reviewed trials - approximately 14.9% for semaglutide (STEP 1) and up to 20.9% for tirzepatide (SURMOUNT-1) under trial conditions

Food and Drug Administration has identified certain bulk drug substances used in compounding as substances that may present significant safety risks, and BPC-157 has been discussed in that regulatory context