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This upregulation of the GH receptor potentiated the proliferative effects of growth hormone, as evidenced by increased cell proliferation (MTT assay) and proliferating cell nuclear antigen (PCNA) expression
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Conversely, either germline knockout or antisense oligonucleotide knockdown of FGFR4 expression in mice enhances hepatic fat oxidation, glucose metabolism, and insulin sensitivity (308310) while reducing hepatic steatosis (308, 309)
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