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When serum creatinine is the only measure of renal function available, the following formula (based on sex, weight, and age of the patient) should be used to estimate the creatinine clearance in adults: Although the pharmacokinetics of fluconazole has not been studied in children with renal insufficiency, dosage reduction in children with renal insufficiency should parallel that recommended for adults

It was known that the AT4G23100 gene encodes the gamma-glutamylcysteine synthetase catalyzing the reaction between Glu and cysteine for generation of glutamylcysteine in the GSH biosynthesis pathway 24