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This is the mechanism that makes TB-500 relevant to injuries that involve slow or stalled healing: when the local repair response has exhausted its resources, TB-500 recruits fresh cells from the surrounding tissue and circulatory system into the damage zone
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LncRNAs such as PWARSN, SNHG7, and MALAT1 have been demonstrated to drive tubular damage and the progression of DKD by activating the pyroptotic cascade (180182)
Current evidence suggests that the output of this module is context-dependent and may be particularly influenced by substrate uptake, oxidative stress within the tissue microenvironment, and the inflammatory stage
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