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The authors would like to acknowledge the operative room, intensive care unit and laboratory teams, which contributed to Ethics declarations Competing interests The authors declare no competing interests
GLP1/E therapy also elicited specific changes in the hypothalamic proteomic profile in PNA mice, upregulating proteins involved in the metabolism of non-coding RNA, signaling of nuclear receptor and estrogen-dependent gene expression and downregulating pathways involved in apoptosis, signaling by insulin receptor and cellular responses to starvation
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There is not yet a proposed mechanism for how antibiotic treatment affects tight junction expression in specific regions of the brain in these studies, but it could be through changes in metabolite composition or cytokine involvement
