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GLP-1 is derived by proteolytic processing of the proglucagon protein (see the Gut-Brain Interrelationships and the Control of Feeding Behaviors page for more details)
The 12 mg dose produced the most dramatic weight loss results but also the highest incidence of adverse events
The SELECT cardiovascular outcomes trial showed that semaglutide 2.4 mg significantly reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in patients with established cardiovascular disease and overweight or obesity, even without type 2 diabetes
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