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The downstream effects include: Synaptogenesis : Formation of new synaptic connections in hippocampal neurons, driven by c-Met-mediated activation of PI3K/AKT and MAPK/ERK signaling cascades Spinogenesis : Growth of new dendritic spines, the structural substrate for excitatory synaptic transmission Neurotrophic support : In cell-based neurotrophic assays, Dihexa demonstrated potency approximately seven orders of magnitude greater than BDNF The HGF/c-Met pathway is distinct from the BDNF/TrkB and NGF/TrkA pathways targeted by most nootropic peptides

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doi: 10.4161/cbt.7.8.6284 58 LuCLiaoZCaiMZhangG

Importantly, despite the existing evidence for low-level protein translation in erythrocytes [41], protein synthesis in mature erythrocytes is negligible or virtually absent, and erythrocytes cannot regulate cell death by production of cell death-associated proteins