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Continued vigilance is essential to support safe administration across heterogeneous cohorts
doi:10.1016/0306-9877(88)90082-5
Long-term risks include: gallstones chronic gallbladder inflammation need for gallbladder removal (cholecystectomy) recurrent biliary pain Thyroid Tumor Risk (Black Box Warning) Several GLP-1 drugs carry an FDA boxed warning for thyroid C-cell tumors and Medullary Thyroid Carcinoma (MTC), based on long-term rodent studies
The last factor is particularly relevant in treatments that depend on the antioxidant/ pro-oxidant property of vitamin C, because it can be readily manipulated and controlled in vivo to achieve desired effects [34]
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