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Duration is capped by what the evidence covers, not by tolerance: no tolerance buildup has been described, but no dose-response curve was ever established either, and twelve weeks at 500 mcg daily would be a 42 mg course that nothing in the record supports
Semaglutide is a licensed prescription medicine that has undergone rigorous clinical evaluation and is approved by the MHRA and recommended by NICE (TA875) for weight management in eligible patients, whereas berberine is an unlicensed food supplement with limited and lower-quality evidence
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L., Kim, E
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