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Used or expired pens should be disposed of according to local regulations for sharps and pharmaceutical waste

Newer therapies are emerging and currently under study for the management of HE targeting traditional mechanisms of ammonia clearance in addition to novel mechanisms related to altering gut microbiome, reducing inflammation and oxidative stress, protecting endothelial integrity, and modifying neuronal responses (Fig

Bezin J, Gouverneur A, Penichon M, Mathieu C, Garrel R, Hillaire-Buys D, et al

However, it appears GLP-1 receptor agonists like Wegovy, and perhaps others such as tirzepatide, retatrutide and survodutide, may also help treat one of the most common illnesses in the world that is often hidden in plain sight fatty liver disease