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Canada also has safeguards to counteract evergreening: Section 5 of the PM(NOC) Regulations allows generics to challenge unjustified patents listed on the Patent Register to gain early access to the Canadian market

injection and tail-tip-bleeding was performed from each animal at 20, 40, 60, 120, and 240 min after injection, sampling 2025 L of blood per time point as illustrated in (Fig

Weight changes at this stage are often modest