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Nat Rev Clin Oncol 2018;15:382-96

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[END CALLOUT BOX] GLP2 Research Applications & Key Findings Type 2 Diabetes Management SURPASS Clinical Trial Program The SURPASS phase 3 clinical program enrolled over 6,000 participants across five global registration trials, evaluating GLP2 across the type 2 diabetes treatment continuum

Gastrointestinal Motility Research The GHS-R1a receptor is expressed not only in the pituitary and hypothalamus but throughout the gastrointestinal tract reflecting the physiological role of ghrelin as a gut-derived hormone regulating gastric motility and appetite