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Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination
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Saibal K Biswas, Danny McClure, Luis A Jimenez, Ian L Megson, Irfan Rahman - Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity - Antioxid Redox Signal - Jan-Feb 2005
Triple-agonist means the activation of three receptors at once as opposed to a mono-agonist (one receptor) and dual-agonist (two)
