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(1) This may upregulate growth hormone (GH) synthesis, which is a hormone with catabolic potential towards fat cells, and also may possess anabolic potential via a mediator called insulin-like growth factor 1 (IGF-1) The research suggests that it may produce rapid, concentration-dependent, pulsatile GH elevations, yielding GH pulses roughly 20- to 30-fold above basal values and potentially close to other GHSs such as GHRP-6 and GHRP-2

For example A person weighing 50 kg would require close to 1000-2000 mg of glutathione daily

A 10-year longitudinal follow-up of a retrospective cohort comprising 159 patients with PCOS treated with metformin reported that the total testosterone and androstenedione decreased to 15.4 47.9% and 11.3 46.4% within first year, with further decrease in total testosterone and androstenedione to 37.8 61.8 and 24.8 40.5% at the fifth year of the follow-up (38, 39)