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5.5 Experimental model standards Animal and cellular models remain essential, but model choice should match the clinical question
The compound is a tripeptide consisting of cysteine, glycine, and glutamic acid, and it exists in two states: the reduced state (GSH) and the oxidized state (GSSG)
The study was conducted in a mouse model with BRAF and NRAS mutations, as well as wild-type melanoma xenografts and allografts of highly metastatic melanoma (222)
Trials so far are small and sometimes inconclusive, and the ideal dose, schedule, and stacking approach remain open questions
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