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The earlier Phase 2 trial ran 48 weeks

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They mimic a natural gut hormone called GLP-1, which is released after eating and helps coordinate metabolism in several ways: they slow how quickly food leaves the stomach, increase feelings of fullness in the brain, reduce appetite, and help the pancreas release insulin when blood sugar rises while also lowering glucagon, a hormone that tells the liver to release stored sugar

Even losing that first bit of weight has made such a difference: my knee pain has decreased, Im breathing better at night, and I was even planning to see a doctor for sleep apneabut now Im canceling the appointment because I feel so much better