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Cardiovasc Drugs Ther 1990;4:481-6
Some of their functions include: Protecting the stomach lining from damage Reducing excess stomach acid Stimulating the production of gut-protective mucous Helping to regulate kidney function Improving blood flow to the liver So by blocking the production of prostaglandins, were not just stopping the process of inflammation and pain, were blocking all of these other functions, including those that support and protect the gut
The accumulation factor (R 1015 for semaglutide with once-daily dosing) describes the ratio of steady-state exposure to single-dose exposure, not a process of unlimited accumulation
Conclusion Endogenous gut-derived GLP-1 and GLP-1RAs are both agonists of the GLP-1R
