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In the United States alone, the annual direct medical costs associated with RA are estimated to exceed $19 billion, with indirect costs such as lost productivity further amplifying the economic impact 5

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Hence, the attachment of an extra tail seems unnecessary

30 Among the pathways activated by IR and IGF-1R signaling are the RASRAFMEK1/2extracellular signal-regulated kinase (ERK)-1/2 pathway 34 and the phosphatidylinositol-3-kinase (PI3K)AKTmammalian target of rapamycin (mTOR) pathway, two fundamental pathways for tumor cell proliferation and survival (Figure 2)