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Dig Liver Dis 2007;39:922-8
Similar trends were observed in a mouse model of pancreatic ductal adenocarcinoma (PDAC) ( LSL-Kras G12D/+ Trp53 f/f Pdx1 cre (KP / C) mice 28 ) and in humans with renal cell carcinoma 29 (Extended Data Fig
This process requires a lot of energy and, as a byproduct, creates its own free radicals
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