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The two main incretins in humans are glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
Switching from orforglipron to an injectable GLP-1 is simpler pharmacokinetically, since orforglipron's effects clear within a day or two of the last dose
A sub-therapeutic GLP-1 dose may be insufficient to counteract these forces once the initial weight loss plateau is reached
The connection between blood clots, DVT, and PE while taking semaglutide drugs will be further examined by the medical community
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