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Although the insulinotropic effect of GIP is diminished in patients with type 2 diabetes, studies have found that GIP receptor agonists can induce a degree of weight loss and, when used in combination with GLP-1, can produce synergistic effects, enhancing blood glucose reduction and weight loss

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The GLP-1 agonist handles post-meal glucose spikes and provides appetite suppression that counteracts insulin-related weight gain