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Whilst PT-141 is a variant of Melanotan, Melanotan 2 is primarily researched for tanning it may have indirect effects on libido due to its melanogenesis-stimulating properties, whereas PT-141 directly targets sexual function by activating melanocortin receptors in the brain

An HR of 0.79 in favour of orally administered semaglutide compared with placebo was observed, but this 21% reduction in MACE did not reach statistical significance ( p = 0.17 for superiority)

51 Additionally, studies incorporating imaging data, visual function data, and prospective trials are warranted to further characterize the true effect of GLP-1 RA use on ocular diseases

For patients seeking proven, effective GLP-1 treatment, injection remains the evidence-backed choice