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As with other retatrutide trials, weight loss and HbA1c improvement were lower than in the non-diabetic TRIUMPH-1 population (28.3%) a pattern consistent across the GLP-1 drug class, where type 2 diabetes reduces the magnitude of weight loss achieved

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Results Sequence variations in monotreme Gcg genes are present in regions known to be important for the regulation of protein function Gcg , Glp-1r , Gip and Dpp-4 genomic sequences were identified in the platypus genome database

Clinical observations show that patients who experience this side effect report it as mild-to-moderate in severity, and most describe improvement by week four