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Drug Safety , 46(7), 789-802
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However, only the injectable form has been available because peptide drugs are usually not suitable for administration via the oral route, as they present low oral bioavailability, are inactivated when they reach the gastrointestinal tract, and have low rates of diffusion into the cell [31, 32]
Furthermore, compared with the HCD group, the HCD + ALC group showed significantly decreased Srebp2 , Hmgcr , Ldlr , Apob , and Abcg8 mRNA levels and a significantly increased Abcg5 mRNA level (Figure 3H)
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