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Specifically, ferroptosis occurs in the pancreatic tissue of T2DM model rats and high glucose-induced INS-1 cells, with increased iron content and expression of ROS and ACSL4, while GPX4 expression is downregulated [86]
Moreover, the LepR neurons specifically within the dDMH were recently studied for their role in activating brown adipose tissue (BAT) thermogenesis, while not altering food intake [77]
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