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Both are dual agonists designed to produce superior weight loss compared to single-receptor medications like semaglutide , but their different receptor combinations create distinct metabolic effects, side effect profiles, and practical considerations that matter when choosing between them

Rapid weight loss can also lead to gallstones but this is an effect of losing a lot of weight very quickly, not of semaglutide itself

Moreover, it is not possible to clarify whether these effects are fully secondary to weight reduction and if this drug class has other beneficial hepatocellular activities beyond weight loss

Effects of PYY336and GLP-1 on energy intake, energy expenditure, and appetite in overweight men