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While elevated MMA blood concentration is considered the specific indicator of deficiency (19), other clinical assays are often used as biomarkers of vitamin B 12 status sometimes in combination

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In a very practical sense, B12 and other water-soluble vitamins are the safest and easiest nutrients to supplement because your body takes what it needs and gets rid of what it doesnt

Their activation near the blood-brain barrier, in the perivascular space, can increase vascular permeability and prime microglia, the resident immune cells of the central nervous system 21