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With a 20-day active period and 4 months off, the total annual protocol commitment is 60 active days spread across the year
Clinical trial data from the SURMOUNT series shows these incidence rates: Nausea: approximately 20 percent of patients Diarrhea: approximately 16 percent of patients Vomiting: approximately 9 percent of patients Constipation: varies by dose level Decreased appetite: expected therapeutic effect Abdominal pain: less common but reported Most gastrointestinal side effects are mild to moderate and occur during the first few weeks of treatment or after dose increases
New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio
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