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First, treatment allocation was not randomized, raising the potential for residual confounding despite extensive pretreatment covariate adjustment through propensity score matching

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden