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A medicine is assigned a Boxed warning if it meets any of the following criteria: It has been associated with a serious side effect that could cause death or permanent disability The risk of severe side effects can be reduced if people and prescribers comply with specific administration or dosing guidelines, such as side effect monitoring, being alert for interacting medicines, and taking note of the recommended and maximum dosage

Who shouldnt take Contrave Contrave is a prescription weight loss pill for people who have obesity or are clinically overweight with a weight-related medical condition

It is intended for research use only, not for human consumption

(Farr et al., 2019) found increased orbitofrontal cortex activation when controlling for BMI/weight changes