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In men, excess adiposity is associated with decreased testosterone, increased estradiol from aromatization, impaired spermatogenesis, and erectile dysfunction

This can take several shots to correct over several weeks in total, as it takes time for your body to both absorb the vitamin B12 and use it to repair any damaged tissues or boost cell DNA synthesis back to normal levels
10.1002/ctm2.372 Clin Transl Med

Kidney issues: Dehydration from nausea, vomiting, or diarrhea can worsen kidney function
