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Lepore JJ, Olson E, Demopoulos L et al (2016) Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on cardiac function, cardiac metabolism, and exercise capacity in patients with chronic heart failure and reduced ejection fraction

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Over 65% of healthcare providers now prefer GLP-1-based therapies as a first-line injectable option for type 2 diabetes management due to improved glycemic control outcomes

In addition, systemic administration of recombinant MG53 causes systemic insulin resistance and metabolic syndrome in mice, by blocking the insulin receptor (234)