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The BW^0.8 exponent is consistent with retatrutides own matched-dose arm pairs in Rosenstock 2023 4 mg ID2 at 108.3 kg vs 4 mg ID4 at 93.1 kg (predicted Cav,ss ratio 1.13, observed 1.18, 4.6% error), and 8 mg slow at 98.4 kg vs 8 mg fast at 95.9 kg (predicted 1.02, observed 1.04, 1.5% error)

Unexplained elevated B12 levels warrant medical investigation including liver function tests, renal function assessment, and full blood count

The advisory committees recommendation does not mean the drugs have been approved by the FDA

For gastrointestinal indications, oral BPC-157 is appropriate because the gut is the target and the peptide does not need to travel further