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Note: Medication is only prescribed when clinically appropriate

These trials have determined the safest and most effective dose for these medications to treat specific medical conditions

1 Introduction Type 2 diabetes mellitus (T2DM) is a chronic hyperglycemia-induced metabolic disease ( Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)

47,48 By emulating the biological activity of natural GLP-1, GLP-1RAs effectively fulfill the role of GLP-1, effectively lowering blood glucose levels without increasing the risk of hypoglycemia and demonstrating favorable safety profiles