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Excess adiposity, insulin resistance, inflammation and higher oxidative stress are hallmarks of type 2 diabetes and obesity, which are proven to alter endothelial dysfunction and affect haemodynamics resulting in elevated blood pressure [28, 29]
[Accessed 18 March 2026].
Methionine is an essential amino acid and a precursor for S-adenosylmethionine (SAM), a vital methyl donor in various biochemical reactions (19, 20, 25, 71, 76)
Existing NICE-approved therapies, including semaglutide and tirzepatide, already offer substantial benefits for eligible patients and are available through NHS pathways
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