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Visible improvements typically emerge after four to eight weeks of consistent use
When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed
This depends on your degree of deficiency and individual response
2021 May 9;22(9):5010
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