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Ascorbate free radical as a marker an epr study of oxidative stress

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Upregulated: collagen synthesis genes (COL1A1, COL3A1), antioxidant genes (SOD1, SOD3), DNA repair genes (GADD45A) Downregulated: inflammatory cytokines (IL-6, TNF-), metalloproteinases (MMP-2, MMP-9), pro-fibrotic mediators Net effect: shift from tissue destruction and inflammation toward repair and remodeling This breadth of gene modulation is unusual for a single tripeptide and has generated significant research interest in fields ranging from dermatology to neuroscience

2.2 Animal models Animals including mice, rats, rabbits, dogs, sheep and Zebrafish have been used for GIO modeling [33,34,35,36,37]