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Here we present the antioxidant GSH as a potential unexplored way for further investigation as intervention to counteract inflammaging, premature inflammaging, inflammatory diseases and long-COVID-19-syndrome, since GSH levels are correlated with tissue and organ damage, disease severity and progression, and disease outcome (294296, 298, 299)

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Graphical Abstract Highlights ROS imbalance promotes DNA damage and drives breast cancer initiation and progression

Thus a reduction in a protective antioxidant such as UA may result in increased oxidative stress and subsequent damage