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If you have PCOS and notice decreased libido on semaglutide, requesting a testosterone level check is a reasonable first step that your dosage protocol should account for
Key Takeaways TRIUMPH-4 Phase 3 results (December 2025): 28.7% average body weight loss at 68 weeks on the 12mg dose vs 2.1% on placebo TRIUMPH program scope: Over 5,800 participants across four core trials covering obesity, type 2 diabetes, cardiovascular outcomes, and knee osteoarthritis Additional trials enrolling (April 2026): TRIUMPH-7, -8, and -9 are actively recruiting at Lilly trial sites How to enroll: Search ClinicalTrials.gov for retatrutide or call Lilly at 1-877-CTLILLY Retatrutide is investigational: Not FDA-approved as of April 2026
Going lower accelerates muscle loss, hair loss, and nutrient deficiencies
It does not permanently eliminate hormonal susceptibility or genetic predisposition
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