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13 Less common but important side effects include: Gallstones (rare) Kidney problems, especially in older adults who already have kidney disease Significant weight loss, which could be concerning for frail elderly people Special considerations for older adults: Stomach problems can lead to dehydration, which can be more serious in older adults
Circadian Rhythms of Plasma Renin Activity and Aldosterone: Changes Related to Age, Sex, Recumbency and Sodium Restriction
However, tirzepatides package insert, for example, warns that use of this medication may reduce the efficacy of hormonal contraceptives and advocates for non-oral contraceptive methods
Figure 4: Reduction in body weight from baseline level in treatment groups administered treatment with cagrilintide, semaglutide, or a combined treatment of both peptides
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