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Combined GLP-1 and GIP receptor agonism at appropriate doses shows a safety profile similar to high-dose single-agent therapy, with nausea and gastrointestinal adjustment as the primary tolerability issuestypically resolving within 48 weeks
For many patients, gastrointestinal side effects gradually improve as the body adapts to the medication, though the timeline varies by product and individual
The study did not qualify for prospective registration as a clinical trial because there was no study directed intervention
When patients lose weight too quickly, the body depletes fat stores rapidly, including the structural fat in the face and glutes
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