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Published in vitro and animal-model research has examined NNMT inhibition in connection with several areas of scientific interest, including adipocyte metabolism , NAD pathway regulation , mitochondrial function , and cellular energy signalling

NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores

In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals

The compound works through the same NNMT inhibition mechanism in both sexes, though dosing may need adjustment based on body weight