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HRT addresses the root cause rather than managing each symptom with a separate medication
The Braak hypothesis proposes that PD exhibits a multifocal and multitransmitter-driven pathology, providing a framework for understanding its neuropathological progression ( -syn pathology is observed not only within the brains dopaminergic and non-dopaminergic systems but also extensively throughout the peripheral and autonomic nervous systems
however, large-scale controlled human efficacy data are not yet available
The list of identified metabolites in the three assays is shown in Tables 1 and 2
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