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Potential Benefits (preclinical) Senescent-cell clearance: In aged/progeroid mice, FOXO4-DRI selectively cleared senescent cells via the FOXO4p53 mechanism [1] [3]
Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker
The risk of biliary disease has been examined in fewer studies, which may be because gallbladder emptying is impaired
As the field moves toward oral small molecules such as Elecoglipron, balancing innovation with rigorous safety science will remain central to the future of GLP-1 therapeutics
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